- Where are our genomes sequenced?
- Your genomes are sequenced in one of our selected third-party partner labs in either Germany, Denmark, New Jersey (USA) or Hong Kong. Before selecting the best partners to sequence your DNA we ran pilots and reviewed more than 15 genetic labs. All of our partner labs are certified, and we have worked with them to implement special quality workflows, going beyond the normal regulatory measures. We have now setup our own laboratory in L’Aquila, Italy, [ in the university district, near the GSSI PhD school]. Looking forward, more and more samples will be analyzed internally.
- Do you ship your kits globally?
- Yes. We do ship globally. Free shipping.
- What is the delivery time?
- After your purchase, you will generally receive your saliva collection kit in 2-3 business days (free international shipment).
- How can I send back my kit with saliva collected?
- After your purchase, you will receive an email containing an UPS pre-paid return shipping label. You can schedule a pickup online or by calling your local UPS Contact Center.
- What will I get from the sequencing of my DNA?
- Dante Labs analyzes 100% of your DNA, so that we can give you reports on predispositions on any genetic disease. You will receive: Health Condition Report, Wellness and Longevity Report, Reaction to Medication Report and a Customized Report.
- Who makes our reports?
- Customized reports on your selected diseases and conditions of interest are generated by the Dante Labs bioinformatics team. The Wellness & Longevity Report is generated in partnership with Sequencing.com.
- How will I receive my raw data?
- When your results are ready, your Dante Labs account will have a link to download the VCF file(s) directly onto your computer or mobile device (about 150-200 MB of space). You can also ask us to send your BAM and FASTQ files via a hard drive if you wish (about 200-250 GB).
- What can I use to read my VCF?
- We suggest using the Eve App by our partner Sequencing.com, directly on the Sequencing.com website. There, you’ll find a free or a paid version of the app (still less than $10!). Some third-party software tools were developed for microarray data and therefore, are not the best at interpreting VCF files generated from the next generation sequencing technologies we use. However, the Sequencing.com Eve App works very well with VCF files, so we highly recommend it!
- How can I create a gVCF file from a BAM?
- We would suggest using the gVCF app by our partner Sequencing.com. You can access the app on the Sequencing.com website, costing you less than $20.
- Where is our data stored?
- Your data is stored in our secure Amazon Web Services (AWS) cloud in the United States and Europe.
- What genes do you analyze?
- Whole Genome analyzes all the genes in your DNA. Whole GenomZ and Whole GenomeM analyze all of your genes and the space between them. This means, every letter in your DNA is sequenced!
- I can’t find some SNPs in your VCF that are in my 23andMe file. Why?
The 23andMe raw data file includes the letters (AA, CT, etc.) for about 650,000 SNPs, regardless of whether you have actually have differing genetic variants (from the reference genome) or not.
On the contrary, the VCF file, based on your entire DNA (all your SNPs!), whittles down the SNP data to provide you with the SNP variants that specifically differ from the reference genome.
Therefore, if you cannot find some SNPs, in your VCF file compared to your 23andMe file, it means that you do not have variants in those SNPs. This means that your SNPs ‘match’ the reference genome (meaning you’re healthy!) and the VCF has removed them so have immediate access to the SNPs where do differ.
- How do you keep your prices so low?
- Our mission is to make genetics accessible to everyone. Price has been a barrier for many people to access their genetic data for too long. Using an Amazon approach, we identified inefficiencies in typical genetic laboratory workflows. We found that most of the costs were not in the DNA sequencing process, but in the management of the samples before the sequencing, including DNA extraction, or in the bioinformatics processing after the sequencing. We have eliminated these inefficiencies and leveraged economies of scale to finally pass the cost savings to you.
- Are you compliant with the GDPR?
- Yes, we are fully compliant with the GDPR.
- Do I need to send you a blood sample to analyze my DNA?
- No. At Dante Labs, we work with saliva samples. This is because saliva is a non-invasive and effective way to collect your own DNA.
- How do you protect your patients’ privacy?
- Dante Labs is built on trust. We respect your privacy and protect it with strong encryption and strict policies that govern how all of the data is handled.
We are compliant with the GDPR and the UK Cyber Essentials, required by the National Health Service. We also have a sophisticated cloud structure to protect your data.
Furthermore, after you send us your saliva sample, your data, samples, results and reports are only identifiable by the barcode on the saliva collection tube.
Lastly, your reports and results include no personal identification information, meaning if lost you will remain anonymous.
- What is the customized report and how do I choose one?
The customized report is an additional option that we provide (free of charge) to patients who have a strong, justified interest for a specific condition or disease (ex. Epilepsy, Ehler Danlos, Periodic Paralysis, etc.).
This report has proven very useful, especially for patients with Rare Diseases.
For example, if you choose “Periodic Paralysis”, then we will generate a Periodic Paralysis virtual panel, containing all the variants associated with Periodic Paralysis. On top of this, we will generate a report with variants from other diseases, but which have similar symptoms called the ‘Secondary Report’.
- What is the Secondary Report I receive together with the Customized Report?
- The Secondary Report includes variants and genes of diseases with similar symptoms to your chosen disease of interest. We have experienced that with complex diseases, up to 20% of patients have been misdiagnosed with the wrong disease. Therefore, this Secondary Report has proven to be a very useful tool for both patients and doctors to achieve a precise diagnosis, and prevent the ‘diagnostic odyssey’ experienced by rare disease patients.
- Where can I learn more about genetics?
The NIH Genetics Home Reference is a great resource for fundamental topics related to human genetics: